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KMID : 1161420150180080921
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Journal of Medicinal Food
2015 Volume.18 No. 8 p.921 ~ p.928
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Artemisia asiatica Nakai Attenuates the Expression of Proinflammatory Mediators in Stimulated Macrophages Through Modulation of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways
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Kim Eun-Kyung
Tang Yujiao
Cha Kwang-Suk
Choi Hee-Ri
Lee Chun-Bok
Yoon Jin-Hwan
Kim Sang-Bae
Kim Jong-Shik
Kim Jong-Moon
Han Weon-Cheol
Choi Suck-Jun
Lee Sang-Min
Choi Eun-Ju
Kim Sang-Hyun
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Abstract
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The present study aimed to examine the anti-inflammatory effects and potential mechanism of action of Artemisia asiatica Nakai (A. asiatica Nakai) extract in activated murine macrophages. A. asiatica Nakai extract showed dose-dependent suppression of lipopolysaccharide (LPS)-induced nitric oxide, inducible nitric oxide synthase, and cyclooxygenase-2 activity. It also showed dose-dependent inhibition of nuclear factor-κB (NF-κB) translocation from the cytosol to the nucleus and as an inhibitor of NF-κB-alpha phosphorylation. The extract's inhibitory effects were found to be mediated through NF-κB inhibition and phosphorylation of extracellular signal-regulated kinase 1/2 and p38 in LPS-stimulated J774A.1 murine macrophages, suggesting a potential mechanism for the anti-inflammatory activity of A. asiatica Nakai. To our knowledge, this is the first report of the anti-inflammatory effects of A. asiatica Nakai on J774A.1 murine macrophages; these results may help develop functional foods possessing an anti-inflammatory activity.
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KEYWORD
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Artemisia asiatica Nakai, ERK1/2, p38, NF-κB
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